Pushing the envelope: expanding fertility sparing treatment of endometrial cancer

Fertility-sparing treatment of endometrial cancer: options, outcomes and pitfalls

Endometrial cancer is the most common gynecologic malignancy in the United States, with over 40,000 cases diagnosed each year. While a majority of cases are diagnosed in post-menopausal women, up to 14% of cases will be in pre-menopausal women, including 4% diagnosed in women less than 40 years of age. While hysterectomy with bilateral salpingo-oophorectomy with assessment of the retroperitonea...

Laparoscopic Fertility Sparing Management of Cervical Cancer

Breast cancer in the setting of fertility-sparing treatment for endometrial cancer

•Progesterone therapy is a commonly used alternative to surgical management for women with endometrial cancer who desire fertility preservation.•Prior research suggests that progestins may contribute to breast tumorigenesis.•We report a patient diagnosed with progesterone receptor positive breast cancer during hormonal treatment of endometrial cancer.

Fertility-sparing treatment of low-grade endometrial stromal sarcoma.

Low-grade endometrial stromal sarcoma (ESS) is a kind of uterine malignancy. Total hysterectomy and bilateral salpingo-oophorectomy was the main treatment. We evaluate the feasibility of fertility-sparing management in five patients with low-grade ESS who desired for childbearing. The patients aged 28-36 years old presented with symptoms of menometrorrhagia or without symptom. Ultrasound examin...

Progestins in the fertility-sparing treatment and retreatment of patients with primary and recurrent endometrial cancer.

Endometrial cancer is the most common gynecologic cancer in developed countries. Approximately 3%-14% of endometrial cancers are diagnosed in young women under 40 who want to preserve their fertility. The incidence of endometrial cancer in this age group is increasing, for which fertility-sparing therapy is increasingly used because it is one of the most important quality of life issues in thes...